I have three recivers two copies of WSJTX running FT8 and WSPR both with CAT control. Shut all the software down and restart, it should all come back working mine does. It might not be the case for you just check it all out. Reconfig your data software to the appropiate sound device (and CAT control if you set this up) current configured in the RX's dont change them from this as SRuno will just change them back next time you restart SDRuno. I suspect that when SDRuno application restarts its not restoring the sound output device back to the relevant reciver but probably stepping through the audio device list and assigning on a first found basis. There is a trap here ! Stop and restart SDRuno application you might find that the output device for each RX has been changed. Get your software running and listening to the output of the appropiate audio inputs from your audio devices. You need to get each RX audio output set up then stop and play sdruno in the main panel to get the RX audio output sent to the relevant audio device. Turn off any monitoring on your virtual cable drivers this will just mix up audio between devices and will create very confusing waterfalls. I have plugged a set of headphones into my internal sound card just so I can hear it if I wish.

The realtek and virtual cable are for SDRplay. I am using the USB sound card as my system sound device with a set of speakers. Internal sound card (realtek sound using inbuilt mixer basically a virtual cable) Well I have a slightly different config in window ten.

Windows virtual cable